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KMID : 0617320010100010163
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Journal of Pharmacetical Sceiences Ewha Womans University
2001 Volume.10 No. 1 p.163 ~ p.166
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SYNTHESIS OF NOVEL 3´-DEOXY-3´-C-HYDROXYMETHYL NUCLEOSIDES WITH CONFORMATIONALLY RIGID SUGAR MOIETY AS POTENTIAL ANTIVIRAL AGENTS
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Chun, Moon Woo
Kim, Myung Jung/Jo, Un Hee/Kim, Joong Hyup/Kim, Hee-Doo/Jeong, Lak Shin
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Abstract
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Based on the fact that the ring expanded 3´-C-hydroxymethy analogue of oxetanocin A exhibited potent antiviral activity two types of conformationally rigid 3´-C-hydroxymethyl derivatives in which 2´hydroxyyl group is linked to the 4´-position or to the 6´-position were synthesized starting from 1.2:5.6-di-O-isopropylidene-D-glucose, respectively.
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